Toward regeneration of articular cartilage
نویسندگان
چکیده
منابع مشابه
Electrical stimulation of articular cartilage regeneration.
The fact that bone is stress electrogenic is well substantiated. Becker and colleagues have proposed that this property is the biological signal that regulates Wolff's law, whereas others have observed osteogenic responses to electrical voltages and currents. Becker and Murray detected electrical control signal characteristics in fractured long bones. The above findings and the work of Smith, w...
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Cartilage damage is typically treated by chondrocyte transplantation, mosaicplasty, or microfracture. Recent advances in tissue engineering have prompted research on techniques to repair articular cartilage damage using a variety of transplanted cells. We studied the repair and regeneration of cartilage damage using layered chondrocyte sheets prepared in a temperature-responsive culture dish. W...
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Advanced cell-based therapies are promising approaches for stimulating full regeneration of cartilage lesions. In addition to a few commercially available medicinal products, several clinical and preclinical studies are ongoing worldwide. In preclinical settings, high-quality cartilage tissue has been produced using combination strategies involving stem or progenitor cells, biomaterials, and bi...
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Mesenchymal stem cells (MSCs) have emerged as a promising option to treat articular defects and early osteoarthritis (OA) stages. However, both their potential and limitations for a clinical use remain controversial. Thus, the aim of this systematic review was to examine MSCs treatment strategies in clinical settings, in order to summarize the current evidence of their efficacy for the treatmen...
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The regeneration of articular cartilage damaged due to trauma and posttraumatic osteoarthritis is an unmet medical need. Current approaches to regeneration and tissue engineering of articular cartilage include the use of chondrocytes, stem cells, scaffolds and signals, including morphogens and growth factors. Stem cells, as a source of cells for articular cartilage regeneration, are a critical ...
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ژورنال
عنوان ژورنال: Birth Defects Research Part C: Embryo Today: Reviews
سال: 2013
ISSN: 1542-975X
DOI: 10.1002/bdrc.21042